3Helix CHP Indication: MASH (formerly NASH)

Visualize and quantify MASH disease activity

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Introduction

3Helix Collagen Hybridizing Peptides (CHPs) are short peptides that selectively target damaged and remodeling collagen for applications in therapeutics, cosmetics, drug delivery systems, and life science tools.

Summary

Metabolic Dysfunction-Associated Steatohepatitis (MASH) Indication: Target damaged collagen with collagen hybridizing peptides (CHPs) for an accurate assessment of MASH disease activity level.

Indication Note

Stratify patients by disease activity using damaged collagen to improve understanding of treatment response.

Metabolic dysfunction-associated steatohepatitis (MASH), historically known as non-alcoholic steatohepatitis (NASH), is a dynamic disease marked by periods of fibrotic activity that result in damage to collagen. Quantifying damaged or remodeling collagen in liver samples could allow for population stratification by disease activity levels or monitor response to treatment.

Collagen Hybridizing Peptides (CHPs) are the ONLY stain for selectively binding damaged collagen, enabling:

  • Detection of fibrotic disease progression up to two times sooner than traditional staining methods.
  • Potential stratification for clinical trials based on disease activity rather than stage.
  • Excluding non-active fibrosis enables shorter, more cost-effective clinical trials.
  • Possibility to reduce clinical trial length by acting as a secondary endpoint for disease activity.
Graphic showing how CHPs bind with damaged collagen.

Ilex Life Sciences LLC is an authorized distributor of CHP products manufactured by 3Helix, Inc.