Ossiform P3D Scaffolds in cell culture plate
Ossiform P3D Scaffolds in 96-well plate
Ossiform P3D Scaffolds: bone-like 3D cell culture systems
Ossiform P3D Scaffold in forceps
Placing the Ossiform P3D Scaffold into a 12-well cell culture plate
Ossiform P3D Scaffolds under microscrope
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Ossiform P3D Scaffolds: bone-like 3D cell culture systems

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Bring natural bone environments to the laboratory

What are P3D Scaffolds?

Ossiform P3D Scaffolds are xeno-free, bioceramic scaffolds which provide a bone-like niche for in vitro and in vivo studies such as disease modeling, drug screening and bioengineering. The 3D printed bioceramic scaffolds are developed to resemble native bone with respect to both physical and structural properties, such as high contents of β-tricalcium phosphate (β-TCP) and stiffness, as well as macro- and micro-porosities.

The P3D Scaffolds are an easy plug-and-play solution for 3D cell culturing of bone harboring or bone related cell types. The cell culture system is compatible with most common laboratory techniques and does not require major alterations of preexisting protocols and workflows.

P3D Scaffolds provide you with a clinically relevant cell culture system of natural materials and customized structures which allow you to create predictive research models of human physiology and pathology.

Advantages

  • Enable complex co-culturing
  • Maintain relevant cell signaling
  • Support the natural self-organization of cells
  • Easily apply 2D analysis methods
  • For in vitro and in vivo pre-clinical research
  • All P3D Scaffolds are supplied sterile and ready to use

Benefits

  • 100% polymer-free
  • Consist solely of β-tricalcium phosphate (β-TCP)
  • Clinically relevant environment
  • Directly translate from in vitro to in vivo
  • Fully customizable to your research needs
  • Easy-to-use 3D cell culture and drug screening systems

Applications

The P3D Scaffold enables the creation of good disease models, such as bone tumors, and is useful for studying diseases like bone metastasis, osteomyelitis, and osteoporosis. Various cells and pharmaceuticals can be added to the P3D Scaffolds to study how they interact with each other and with the bone within its pores. Potential usages include, but are not limited to, the examples mentioned in the following:

  • Mesenchymal stem cells (MSCs) or osteoblasts can be added onto the P3D Scaffold to study how new bone develops in bone grafts.

  • Bone destruction in osteoporosis/arthritis can be imitated by seeding osteoclasts and macrophages onto the scaffolds.

  • Resorption assays with human osteoclasts for studying osteoclast activation and resorption in various culturing conditions.
  • The development of bone tumors and spreading of cancerous cells through the outer calcified bone matrix can be studied by seeding cancerous cells onto the P3D Scaffolds.

  • Osteomyelitis and the subsequent destruction of bone can be mimicked by adding bacteria and immune cells to the P3D Scaffolds. This enables you to study the mechanisms behind the bacteria's destruction of the hardened calcified bone as well as how bacteria are able to evade the immune system and antimicrobial pharmaceuticals.

Many methods may be used for analyzing the biological activity on the 3D printed structures. Visit our P3D Scaffolds FAQ for more information.

analysis methods compatible with Ossiform P3D Scaffolds

Explore P3D Scaffolds - Standard Design Options

    Choose Design

    Gyroid or grid

    Ossiform P3D Scaffolds allow you to choose from a gyroid or grid design to meet different research needs

    Different infill types fulfill your different research needs.

    Do you need to monitor cell morphology close while the cells are still in culture? Then go for the grid structure, which allows light to pass through the scaffold easily, thereby enabling you to perform regular checkups on your cells. Our data shows that cells will grow from the corners and in.

    Is your research more focused on gaining a model system as natural as possible? Then the gyroid structure is just the right choice for you. Here you will get a randomized organization of the pores, resulting in a variable pore size, making regular checkups while in culture a bit trickier, but leaving you with a more accurate representation of the bone structure.

    Choose Porosity

    Choose between:

    • Porosity 1: 300-400 micrometers
    • Porosity 2: 600-800 micrometers

    Choose Size

    Four standard scaffold diameters are available, designed to fit common cell culture plate sizes. All standard P3D Scaffolds have a height of 3 mm.

    • 5 mm diameter: suitable for 96-well plates
    • 12 mm diameter: suitable for 24-well plates
    • 20 mm diameter: suitable for 12-well plates
    • 30 mm diameter: suitable for 6-well plates

    Four standard scaffold diameters are available, designed to fit common cell culture plate sizes. All standard P3D Scaffolds have a height of 3 mm.

    Extra customizable features

    Special forms, sizes (height, diameter, etc.), and designs of the scaffolds can be requested for a fully customized set of cell culture systems. Please contact us to discuss your specific needs.

    Resources

    Ilex Life Sciences is an official distributor of Ossiform P3D Scaffolds research product line.