Collection: Gonadotropin hormones

For experiments that require large numbers of preimplantation mouse embryos, such as microinjection of zygotes, gonadotropins are administered to females before mating to increase the number of oocytes that are ovulated (i.e., to induce superovulation). Pregnant mare serum gonadotropin (PMSG) is used to mimic the oocyte maturation effect of the endogenous follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG) is used to mimic the ovulation induction effect of luteinizing hormone (LH).

Ilex Life Sciences supports embryology studies, reproductive engineering and superovulation protocols with our broad selection of gonadotropin hormones, including Pregnant Mare Serum Gonadotropin (PMSG), Human Chorionic Gonadotropin (hCG), Human Menopausal Gonadotropin (hMG), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Gonadotropin-Releasing Hormone (GnRH), and synthetic GnRH agonists.

PMSG + hCG: Our PMSG and hCG are commonly used in superovulation protocols for the production of genetically modified laboratory animals, such as genetically engineered mouse models (GEMM) by pronuclear microinjection (transgenic mouse), targeted mutations through CRISPR-Cas9 methods, and embryonic stem (ES) cell-based gene targeting to produce "knockout" mice. PMSG and hCG also have applications with a variety of other species; for example, they may be used in the generation of Xenopus laevis and Xenopus tropicalis eggs or embryos for use in experimental model systems.

To learn more about superovulation in mice, download our Mouse Superovulation Protocol.

To learn more about inducing ovulation in Xenopus laevis, download our Protocol for Inducing Ovulation in Xenopus laevis.