Blog

EndoTrap® Removes Endotoxin from Phage Cocktail Used Against Drug-Resistant P. aeruginosa Infection

January 16th, 2023

Image of a vial of BFC1 bacteriophage cocktail, Image by Merabishvili et al.
EndoTrap® Endotoxin Removal Products were cited in a 2022 Nature article by Van Nieuwenhuyse, Brieuc et al., “Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.” Continue reading...

Monomeric CRP (mCRP): A new key player in Alzheimer's Disease?

June 26th, 2023

Monomeric CRP (mCRP): A new key player in Alzheimer's Disease?

CRP expression may be upregulated in glutamate neurons during specific disease states such as Alzheimer’s dementia. Human and animal studies show that mCRP co-localizes with α-amyloid plaques and with phosphorylated tau protein in the hippocampus. Continue reading....

Comparing Ossiform P3D Scaffolds to Real Bone Slices

Mar. 31st, 2023

Comparing Ossiform P3D Scaffolds to Real Bone Slices
As part of a larger study, Ossiform has compared P3D Scaffolds to slices of real bone. It was determined that there is no significant difference in cell viability after 28 days between slices of bone and the P3D Scaffolds. Continue reading...

Could CBD Alleviate Fibrosis?

Jan. 5th, 2023

Could CBD Alleviate Fibrosis? Blog photo for Sircol Soluble Collagen Assay reference.

Could CBD be an effective antifibrotic therapy? In this blog, we look at a study that investigated the use of CBD to ameliorate fibrosis in preclinical models of systemic sclerosis (SSc) and also non-alcoholic liver fibrosis. Continue reading...

Ossiform P3D Scaffolds Support Normal Morphology of Osteoblasts

Oct. 27th, 2022

Ossiform P3D Scaffolds Support Normal Morphology of Osteoblasts

The latest research from Ossiform has shown that the P3D Scaffolds have great osteogenic properties and that osteoblasts maintain their genotype and morphological phenotype. After culturing osteoblasts for 2-5 weeks, the results are clear. Continue reading...

Rosmarinic Acid May Protect Skin ECM from Negative Effects of BP-3 in Sunscreens

July 19th, 2022

Rosmarinic Acid May Protect Skin ECM from Negative Effects of BP-3 in Sunscreens

Could a compound found in your kitchen protect against the negative effects that a chemical suncreen has on the skin? Today we look at an interesting paper from the Medical University of Bialystok. Continue reading....

Blyscan™ GAG Assay Cited in MPS-IH (Hurler syndrome) In Utero Base Editing Study

July 12th, 2022

Blyscan™ GAG Assay Cited in MPS-IH (Hurler syndrome) In Utero Base Editing Study

The Biocolor Blyscan™ Glycosaminoglycan Assay has been cited in Nature Communications in an interesting study by Bose, Sourav K et al. 2021, “In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease.” Continue reading...

Cell-Degradable (CD) Hydrogels Support Cell Spreading and Migration

June 14, 2022

3-D Life Cell-Degradable (CD) Hydrogels Support Cell Spreading and Migration

A hydrogel that allows cells to spread and migrate within their in vitro environment is a better mimic of the native in vivo tissue environment. Cell spreading requires MMP cleavage and cell adhesion sites. Continue reading...

Biocolor ECM Assays Used to Evaluate Architecture-Inspired Biomaterials

May 26, 2022

Reinforced biotubes inspired by reinforced concrete

What does reinforced concrete have to do with tissue engineering?

Pulling inspiration from architectural engineering, researchers have developed mechanically reinforced biotubes for arterial replacement and arteriovenous grafting. Continue reading...

3-D Life PVA-CD Hydrogel Used in Microfluidic Platform to Model and Assess Cellular Barriers

May 20, 2022

3-D Life PVA-CD Hydrogel Used in Microfluidic Platform to Model and Assess Cellular Barriers
The Cellendes 3-D Life PVA-CD Hydrogel SG Kit has been cited in Biosensors in an interesting study by Arya Lekshmi Nair et al. 2021, "Parallelizable Microfluidic Platform to Model and Assess In Vitro Cellular Barriers: Technology and Application to Study the Interaction of 3D Tumor Spheroids with Cellular Barriers." Continue reading...

Easily Recover Live or Fixed Cells from Hydrogels

May 10, 2022

3-D Life Dextranase degrades dextran-based hydrogels, allowing easy post-culture recovery of live or chemically fixed cells

Do you need a hydrogel for 3D cell culture that allows for protease-free, post-culture recovery of live or chemically fixed cells? 3-D Life dextran-based hydrogels can be dissolved by addition of 3-D Life Dextranase. This allows the isolation of chemically fixed or live cells after 3D cell culture for downstream processing of cells. Continue reading...

Controllable Micro-Variation of Stiffness in 3-D Life Dextran-CD Hydrogel FG Enables Regulation of hMSCs Behavior In Vitro

April 22, 2022

3-D Life Dextran-CD Hydrogel FG Kit
The Cellendes 3-D Life Dextran-CD Hydrogel FG Kit has been cited in Biofabrication in an interesting study by Zheng Wang et al. 2021, "Spatial micro-variation of 3D hydrogel stiffness regulates the biomechanical properties of hMSCs." Continue reading...

EndoTrap HD® Removed Endotoxin from Emergency Use Phage Cocktail for UTI Treatment

January 19, 2022

Removing endotoxin from bacteriophage
EndoTrap® HD columns were used to remove endotoxin (LPS) from an emergency use phage cocktail in the treatment of a complex, recurrent UTI. Continue reading...

KL-6 as a Biomarker of COVID-19 Severity and Prognosis

November 5, 2021

SARS-CoV-2 virus
In a 2021 study by Deng, Kai et al., “Prognostic roles of KL-6 in disease severity and lung injury in COVID-19 patients: A longitudinal retrospective analysis”, the potential role of KL-6 as a COVID-19 biomarker was examined. KL-6 serum levels were compared between patients with severe COVID-19 cases, mild COVID-19 cases, and healthy controls. Continue reading...

Double Cherry Blossom Leaf Extract Effects Tumor Cell-Cycle and Induces Apoptosis

October 26, 2021

Double Cherry Blossom

An interesting study by Shibato, Junko et al., “Towards identification of bioactive compounds in cold vacuum extracted double cherry blossom (Gosen-Sakura) leaves.”, has investigated the composition of Gosen-Sakura (Double Cherry Blossom) leaf extract and its effects on tumor cells. Continue reading...

Rice Bran Supplementation Mitigates Environmental Enteric Dysfunction (EED) in Weaning Infants

October 1, 2021

Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali

A study by Zambrana, Luis E et al. has found that dietary rice bran supplementation mitigates environmental enteric dysfunction (EED) in weaning infants in Nicaragua and Mali. Continue reading...

Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin

September 16, 2021

Cell Spreading on Fibronectin is Augmented by MGP

A study by S. K. Nishimoto and M. Nishimoto of the University of Tennessee Health Science Center, Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin, has made several interesting observations. Continue reading...

Protocol for Inducing Ovulation in Xenopus laevis

August 13, 2021

Xenopus laevis

As many of our customers are using our PMSG + hCG hormones to induce ovulation in X. laevis, we present to you a protocol for such. Continue reading...

Mouse Superovulation Protocol

August 12, 2021

Ilex Life Sciences PMSG + hCG for superovulation protocols

As many of our customers are using our PMSG + hCG hormones for mouse superovulation, we are posting a mouse superovulation protocol. Continue reading...