3Helix F-CHP Product References

3Helix F-CHP (Collagen Hybridizing Peptide, 5-FAM Conjugate) Product Citations

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3Helix Collagen Hybridizing Peptides (CHPs) are short peptides that selectively target damaged and remodeling collagen for applications in therapeutics, cosmetics, drug delivery systems, and life science tools.

3Helix F-CHP (Collagen Hybridizing Peptide, 5-FAM Conjugate) has been referenced in scientific literature. Below you will find some of the scientific papers that reference 3Helix F-CHP. For more information, please visit 3Helix F-CHP.

  • Johnson, R. M., et al. (2024). Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics. PLoS Pathogens, 20(4), e1011975. doi: 10.1371/journal.ppat.1011975
  • Yu, G., et al. (2024). Evaluating the pro-survival potential of apoptotic bodies derived from 2D-and 3D-cultured adipose stem cells in ischaemic flaps. Journal of Nanobiotechnology, 22(1), 333. doi: 10.1186/s12951-024-02598-x
  • Tran, J. C., et al. (2024). Fluorescein-Based SynNotch Adaptors for Regulating Gene Expression Responses to Diverse Extracellular Cues. bioRxiv. Preprint. doi: 10.1101/2024.06.20.599918
  • DiSabato, D. J., et al. (2024). Microglia-derived TNF is necessary for social stress-induced PERIOD2 HMrCmb in hippocampal myeloid cells, neuroinflammation, and anxiodepressive behavior in male mice. Journal of Neuroinflammation, 21(1), 247. doi: 10.1186/s12974-024-03229-x
  • Pedaprolu, K. C. (2023). Drivers of Fatigue Induced Degeneration in a Mouse Achilles Tendon Explant Model [Doctoral dissertation, The Pennsylvania State University]. Penn State Electronic Theses and Dissertations. Link to dissertation
  • Saxena, P. (2024). Mas-Related G Protein-Coupled Receptor B2 Activation Mediates Bladder Wall Biomechanics [Doctoral dissertation, Michigan State University]. ProQuest Dissertations & Theses Global. Link to dissertation (ProQuest)
  • Yuan, Y., Wang, Y.-C., & Kao, W. (2024). Tbr1/Smad4 double knockout demonstrated that Smad4 played a pivotal role in Tbr1-dependent ECM synthesis and Tbr1-independent ECM degradation for maintaining corneal homeostasis. Investigative Ophthalmology & Visual Science, 65(7), 3647. Link to abstract
  • Pertoll, J. (2024). Analysis of the collagen matrix in periodontal Ehlers-Danlos syndrome [Doctoral dissertation, Medizinische Universität Innsbruck]. Medizinische Universität Innsbruck. Link to dissertation
  • Dong, C., et al. (2024). Zingerone promotes the survival of ischaemic flap via the KEAP1-Nrf2 pathway. Journal of Functional Foods, 119, 106328. doi: 10.1016/j.jff.2024.106328
  • Ren, R., et al. (2024). Targeted delivery of IL-4 to injured cartilage enhances cartilage repair and alleviates osteoarthritis. American Journal of Physiology-Heart and Circulatory Physiology, 326(5), H1204–H1218. doi: 10.1152/ajpheart.00240.2023
  • Pukaluk, A., Sommer, G., & Holzapfel, G. A. (2024). Multimodal experimental studies of the passive mechanical behavior of human aortas: Current approaches and future directions. Acta Biomaterialia. Advance online publication. doi: 10.1016/j.actbio.2024.03.001
  • Lai, Y., et al. (2024). Dihydrocapsaicin suppresses the STING‐mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia–reperfusion injury of perforator skin flap. Phytotherapy Research, 38(5), 2539–2559. doi: 10.1002/ptr.8147
  • Komori, T., et al. (2024). Type VI Collagen Deficiency Causes Enhanced Periodontal Tissue Destruction. Journal of Dental Research, 103(9), 878–888. doi: 10.1177/00220345241257636
  • Yoon, H., et al. (2024). Collagen structures of demineralized bone paper direct mineral metabolism. JBMR Plus, 8(9), ziae080. doi: 10.1093/jbmrplus/ziae080
  • Geervliet, E., Karkdijk, E., & Bansal, R. (2024). Inhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo. Scientific Reports, 14(1), 16897. doi: 10.1038/s41598-024-67788-w
  • Linnane, N., et al. (2024). Assessing microstructural damage in paediatric aortic coarctation tissue during benchtop balloon angioplasty and stenting. medRxiv. Preprint. doi: 10.1101/2024.01.10.24301094
  • Chen, H., et al. (2023). Bioinspired mechanically gradient and tough hydrogel by hybrid crosslinking for cartilage tissue engineering. Acta Biomaterialia, 155, 461–470. doi: 10.1016/j.actbio.2022.11.018
  • Bui, C.-B., et al. (2023). Denatured collagen inhibits neuroblastoma tumor-sphere migration and growth via the LOX/LOXL2 - FAK signaling pathway. Journal of Thermal Biology, 115, 103624. doi: 10.1016/j.jtherbio.2023.103624
  • Pearson, N. R. (2023). High Strain Rate Damage in Cerebral Arteries: A Molecular and Mechanical Analysis [Doctoral dissertation, The University of Utah]. University of Utah Research Repository. Link to dissertation
  • Pomerleau, V., et al. (2023). FOXL1+ Telocytes in mouse colon orchestrate extracellular matrix biodynamics and wound repair resolution. Journal of Proteomics, 271, 104755. doi: 10.1016/j.jprot.2022.104755
  • Pedaprolu, K., & Szczesny, S. E. (2023). Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure. Journal of Biomechanics, 151, 111545. doi: 10.1016/j.jbiomech.2023.111545
  • Amberger, A., et al. (2023). Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome. Frontiers in Immunology, 14, 1157421. doi: 10.3389/fimmu.2023.1157421
  • Chen, G., et al. (2023). Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation. Cell Death and Differentiation, 30(6), 1503–1516. doi: 10.1038/s41418-023-01152-x
  • Ganji, E., et al. (2023). Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice. Science Advances, 9(25), eadf4683. doi: 10.1126/sciadv.adf4683
  • Zhang, G.-P., et al. (2023). Mechanical confinement promotes heat resistance of hepatocellular carcinoma via SP1/IL4I1/AHR axis. Cell Reports Medicine, 4(8), 101128. doi: 10.1016/j.xcrm.2023.101128
  • Li, Y., et al. (2023). Targeted delivery of collagenase to myofibroblasts by fusion with a collagen-binding domain for improved fibrosis therapy. Acta Biomaterialia, 170, 376–388. doi: 10.1016/j.actbio.2023.08.035
  • Li, S., et al. (2022). Non-invasive quantification of collagen damage in articular cartilage using a collagen-hybridizing peptide. Journal of the Mechanical Behavior of Biomedical Materials, 131, 105220. doi: 10.1016/j.jmbbm.2022.105220
  • Hwang, I., et al. (2022). Relationship between molecular structure and mechanical properties of collagen in cooked bovine semitendinosus muscle. Meat Science, 184, 108690. doi: 10.1016/j.meatsci.2021.108690
  • Zhu, H., et al. (2022). Crosstalk between nucleus pulposus cells and macrophages has a pivotal role in intervertebral disc degeneration via the NRF2/NLRP3/caspase-1 pathway: from mechanism to therapy. Autophagy, 18(8), 1841–1863. doi: 10.1080/15548627.2021.2002109
  • Kury, M., et al. (2022). Effect of different collagen degradation methods on the properties of experimental resin composites. Dental Materials, 38(5), 748–758. doi: 10.1016/j.dental.2022.04.020
  • Yang, X., et al. (2022). Collagen Remodeling in Engineered Heart Tissues From Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Cardiac Fibroblasts. Frontiers in Bioengineering and Biotechnology, 10, 926675. doi: 10.3389/fbioe.2022.926675
  • Bhole, A. P., et al. (2022). Mechanical and microstructural response of murine C57BL/6J aorta to supra-physiological biaxial and uniaxial tension. Journal of the Mechanical Behavior of Biomedical Materials, 135, 105342. doi: 10.1016/j.jmbbm.2022.105342
  • Pearson, N. R., et al. (2022). Molecular-Level Collagen Damage is Strain Rate Dependent in Cerebral Arteries Stretched to Failure. SSRN Electronic Journal. Preprint. doi: 10.2139/ssrn.4272553
  • Seelemann, C. (2022). Collagen Denaturation as a Toughening Mechanism in Cortical Bone [Master's thesis, University of Waterloo]. UWSpace. Link to thesis
  • Fachin, J. M. (2022). The Effects of a Myocardial Hydrogel on Duchenne Muscular Dystrophy-Associated Cardiomyopathy [Doctoral dissertation, University of California, Los Angeles]. ProQuest Dissertations & Theses Global. Link to dissertation (ProQuest)
  • Worden, A. N. (2022). A Novel Model to Study Adipose-Derived Stem Cell Differentiation [Doctoral dissertation, University of South Carolina]. Scholar Commons. Link to dissertation
  • Lin, A. H. (2022). Multiscale Characterization of Tendon Failure [Doctoral dissertation, The University of Utah]. University of Utah Research Repository. Link to dissertation
  • Pedaprolu, K., & Szczesny, S. E. (2022). Mouse Achilles Tendons are Resistant to Collagen Denaturation During Cyclic and Monotonic Loading to Failure. SSRN Electronic Journal. Preprint. doi: 10.2139/ssrn.4138919
  • Humeres, C., et al. (2022). Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure. The Journal of Clinical Investigation, 132(3), e146926. doi: 10.1172/JCI146926
  • Wu, Y.-F., et al. (2022). Optimization of a pericyte therapy to improve muscle recovery after limb immobilization. Journal of Applied Physiology, 132(4), 1020–1030. doi: 10.1152/japplphysiol.00700.2021
  • Kularathna, P., et al. (2021). HSP47 is essential for normal collagen secretion and assembly. Journal of Biological Chemistry, 296, 100027. doi: 10.1074/jbc.RA120.014709
  • Pang, K. L., et al. (2021). Mapping local variations in damage, composition and structure of articular cartilage using collagen hybridizing peptides. Acta Biomaterialia, 134, 388–400. doi: 10.1016/j.actbio.2021.07.043
  • Chan, A. H. P., et al. (2021). Non-invasive molecular assessment of articular cartilage degeneration via targeted peptide binding. Acta Biomaterialia, 134, 435–442. doi: 10.1016/j.actbio.2021.07.045
  • Ita, M. E. (2021). Biomechanical & Biochemical Contributions of Matrix Metalloproteinases in Joint Pain: Models, Mechanisms, & Patients [Doctoral dissertation, University of Pennsylvania]. ProQuest Dissertations & Theses Global. Link to dissertation (ProQuest)
  • Yang, G., et al. (2021). Fabrication of centimeter-sized 3D constructs with patterned endothelial cells through assembly of cell-laden microbeads as a potential bone graft. Acta Biomaterialia, 121, 204–213. doi: 10.1016/j.actbio.2020.11.040
  • Hortells, L., et al. (2021). Periostin-expressing Schwann cells and endoneurial cardiac fibroblasts contribute to sympathetic nerve fasciculation after birth. Journal of Molecular and Cellular Cardiology, 154, 124–136. doi: 10.1016/j.yjmcc.2021.02.001
  • Lee, S. J., et al. (2021). A novel collagen hybridizing peptide-based MRI probe for targeted imaging of type I collagen. PLoS One, 16(5), e0246221. doi: 10.1371/journal.pone.0246221
  • Park, J. O., et al. (2021). Collagen-targeting MRI probe for molecular assessment of myocardial fibrosis. Matrix Biology, 99, 18–42. doi: 10.1016/j.matbio.2021.05.005
  • Novais, E. J., et al. (2021). Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nature Communications, 12(1), 5213. doi: 10.1038/s41467-021-25453-2
  • Park, J. H., et al. (2021). Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair. Experimental & Molecular Medicine, 53(9), 1423–1436. doi: 10.1038/s12276-021-00676-x
  • Lou, J., et al. (2022). Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels. British Journal of Pharmacology, 179(2), 301–321. doi: 10.1111/bph.15702
  • Nakamura, T., et al. (2021). Ovariectomy Causes Degeneration of Perivascular Adipose Tissue. Journal of Oleo Science, 70(11), 1651–1659. doi: 10.5650/jos.ess21179
  • Widiapradja, A., et al. (2021). Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes. Cells, 10(10), 2659. doi: 10.3390/cells10102659
  • Noehren, B., et al. (2021). T1ρ imaging as a non-invasive assessment of collagen remodelling and organization in human skeletal muscle after ligamentous injury. The Journal of Physiology, 599(23), 5229–5242. doi: 10.1113/JP281964
  • Golman, M., et al. (2021). Toughening mechanisms for the attachment of architectured materials: The mechanics of the tendon enthesis. Science Advances, 7(48), eabi5584. doi: 10.1126/sciadv.abi5584
  • Kwon, J., et al. (2020). Molecular assessment of engineered cartilage by a collagen-hybridizing peptide. Matrix Biology, 85-86, 68–79. doi: 10.1016/j.matbio.2019.07.008
  • Perez, M. G., et al. (2020). Matrix Metalloproteinase-10 Is a Key Regulator of Inflammation in a Mouse Model of Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition, 70(1), 87–92. doi: 10.1097/MPG.0000000000002505
  • Hwang, J., et al. (2020). Label-free optical evaluation of collagen network remodeling in a decellularized cornea model. Journal of the Mechanical Behavior of Biomedical Materials, 109, 103834. doi: 10.1016/j.jmbbm.2020.103834
  • Li, Y., et al. (2020). Targeting collagen structure to inhibit adhesions. Science Advances, 6(35), eaba2795. doi: 10.1126/sciadv.aba2795
  • Yan, H., et al. (2020). Engineering vascularized and innervated bone marrow analogues. Acta Biomaterialia, 118, 153–160. doi: 10.1016/j.actbio.2020.09.056
  • Armstrong, P. M., et al. (2020). Successive blood meals enhance virus dissemination within mosquitoes and increase transmission potential. Nature Microbiology, 5(2), 239–247. doi: 10.1038/s41564-019-0619-y
  • Brightwell, C. R., et al. (2020). Thermal injury initiates pervasive fibrogenesis in skeletal muscle. American Journal of Physiology-Cell Physiology, 319(2), C277–C287. doi: 10.1152/ajpcell.00337.2019
  • Hortells, L., et al. (2020). A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation. Proceedings of the National Academy of Sciences of the United States of America, 117(35), 21469–21479. doi: 10.1073/pnas.2009119117
  • Steijns, F., et al. (2020). Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome. International Journal of Molecular Sciences, 21(19), 7024. doi: 10.3390/ijms21197024
  • Ansari, M. Y., et al. (2020). Mitochondrial dysfunction triggers a catabolic response in chondrocytes via ROS-mediated activation of the JNK/AP1 pathway. Journal of Cell Science, 133(22), jcs247353. doi: 10.1242/jcs.247353
  • Deguchi, S., et al. (2021). A new mechanism for reduced cell adhesion: Adsorption dynamics of collagen on a nanoporous gold surface. Materials Science & Engineering C, 119, 111461. doi: 10.1016/j.msec.2020.111461
  • Kwon, J. Y., et al. (2019). Localized Delivery of Monosodium Urate Crystals to Tendon Activates the NLRP3 Inflammasome and Induces Tenosynovitis in a Mouse Model. Journal of Orthopaedic Research, 37(2), 431–438. doi: 10.1002/jor.24185
  • Hwang, J., et al. (2019). Characterizing collagen microstructural GRadient In Native and Engineered MEChanics (GRIMEC) via quantitative polarized light microscopy. Soft Matter, 15(30), 6237–6246. doi: 10.1039/c9sm00832b
  • Li, Y., et al. (2019). Targeting Thermally Unstable Collagen to Inhibit Post-Traumatic Osteoarthritis. International Journal of Molecular Sciences, 20(17), 4072. doi: 10.3390/ijms20174072
  • Hwang, J., et al. (2019). Collagen-Targeting Immunoliposomes for Molecular MRI of Myocardial Fibrosis. Materials Today Bio, 3, 100018. doi: 10.1016/j.mtbio.2019.100018
  • Pang, K. L., et al. (2019). Molecular Detection and Assessment of Damaged Cartilage by Collagen Hybridizing Peptides. ACS Biomaterials Science & Engineering, 5(4), 1661–1667. doi: 10.1021/acsbiomaterials.9b00070
  • Hoy, R. C. (2019). The Use of Multiphoton Microscopy to Assess Collagen Quality and Advanced Glycation End-products in the Intervertebral Disc [Master's thesis, Icahn School of Medicine at Mount Sinai]. Icahn School of Medicine at Mount Sinai Academic Works. Link to thesis
  • Russo, I., et al. (2019). Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program. Circulation Research, 124(8), 1214–1227. doi: 10.1161/CIRCRESAHA.118.314438
  • Peck, B. D., et al. (2019). Anterior Cruciate Ligament Tear Promotes Skeletal Muscle Myostatin Expression, Fibrogenic Cell Expansion, and a Decline in Muscle Quality. The American Journal of Sports Medicine, 47(6), 1385–1395. doi: 10.1177/0363546519832864
  • Gannon, A. R., et al. (2019). Regional mechanical properties of healing porcine ligaments depend on collagen fiber alignment. Journal of the Mechanical Behavior of Biomedical Materials, 97, 254–271. doi: 10.1016/j.jmbbm.2019.04.022
  • Khalil, H., et al. (2019). Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. JCI Insight, 4(15), e128722. doi: 10.1172/jci.insight.128722
  • Dvoretskiy, S., et al. (2019). The impact of skeletal muscle contraction on CD146+Lin- pericytes. American Journal of Physiology-Cell Physiology, 317(5), C1011–C1024. doi: 10.1152/ajpcell.00156.2019
  • Motoike, S., et al. (2019). Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis. International Journal of Molecular Sciences, 20(16), 3970. doi: 10.3390/ijms20163970
  • Dai, J., et al. (2019). Microfluidic Disc-on-a-Chip Device for Mouse Intervertebral Disc-Pitching a Next-Generation Research Platform To Study Disc Degeneration. ACS Biomaterials Science & Engineering, 5(4), 2041–2051. doi: 10.1021/acsbiomaterials.8b01522
  • Chan, A. H. P., et al. (2018). Engineering translationally relevant orthotopic models of human glioblastoma. Biomaterials, 183, 67–76. doi: 10.1016/j.biomaterials.2018.08.039
  • Simsa, R., et al. (2018). Systematic in vitro comparison of decellularization protocols for blood vessels. PLoS One, 13(12), e0209269. doi: 10.1371/journal.pone.0209269
  • Converse, M. I. (2018). Trauma-Induced Alterations of Cerebral Vessel Mechanics and Microstructure [Doctoral dissertation, The University of Utah]. University of Utah Research Repository. Link to dissertation
  • Lee, S. J., et al. (2018). Molecular MRI of native and denatured collagen after myocardial infarction. Acta Biomaterialia, 67, 307–318. doi: 10.1016/j.actbio.2017.11.052
  • Szczesny, S. E., et al. (2018). Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics. Journal of Biomechanics, 71, 251–256. doi: 10.1016/j.jbiomech.2018.02.014
  • Quigley, A. S., et al. (2018). In tendons, differing physiological requirements lead to functionally distinct nanostructures. Scientific Reports, 8(1), 4409. doi: 10.1038/s41598-018-22741-8
  • Morris, A. H., et al. (2018). Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds. Biomaterials, 169, 61–71. doi: 10.1016/j.biomaterials.2018.03.049
  • Serrano, R. L., et al. (2018). Impaired renal tubularத்யGB1 (AMPKத்ய1) function protects against diet-induced obesity and nephropathy. American Journal of Physiology-Renal Physiology, 315(6), F1658–F1669. doi: 10.1152/ajprenal.00314.2018
  • Deng, Y., et al. (2018). Loss of HSP47 results in defective collagen co-trafficking from the ER to the Golgi and increased ER stress. Disease Models & Mechanisms, 11(12), dmm036012. doi: 10.1242/dmm.036012

Ilex Life Sciences LLC is an authorized distributor of CHP products manufactured by 3Helix, Inc.