Metastasis-suppressor KiSS-1, E. coli Recombinant Protein, 10 ug vial
Metastasis-suppressor KiSS-1, E. coli Recombinant Protein, 1 mg vial
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Metastasis-suppressor KiSS-1, E. coli Recombinant Protein

A1419010
Regular price
$225.00
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$225.00
Regular price
$268.00
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Description

Metastasis-suppressor KiSS-1 (Kisspeptin-1) Human, recombinantly produced in E. coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (20-138) and has a molecular mass of 12.6 Dalton. The protein is purified by proprietary chromatographic techniques.

Summary

Metastasis-suppressor KiSS-1 (Kisspeptin-1) is a metastasis suppressor protein that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. Kisspeptin-1 functions to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Kisspeptin-1 may regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of KISS1 mRNA results in two protein isoforms. Expression of KiSS1 is localized to specific regions of the hypothalamus in numerous species and is regulated by gonadal steroids and across the estrous cycle. Kisspeptin-1 generates a c-terminally amidated peptide, metastin, which functions as the endogenous ligand of the g-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.

Amino Acid Sequence

MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG

Type

Recombinant Protein

Source

E. coli

Purity

Greater than 90.0%

Formulation

Sterile Filtered colorless solution. The protein solution (1 mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol.

Shipping

Shipped on regular ice packs. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Usage

This product is intended to Laboratory Research Use Only.  This product may not be used a drug, agricultural product, food additives.

Other Names

Kisspeptin-1, KISS-1, METASTIN, Metastasis-suppressor KiSS-1, KISS1, MGC39258.

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