Metastasis-suppressor KiSS-1 (Kisspeptin-1) Human, recombinantly produced in E. coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (20-138) and has a molecular mass of 12.6 Dalton. The protein is purified by proprietary chromatographic techniques.
Metastasis-suppressor KiSS-1 (Kisspeptin-1) is a metastasis suppressor protein that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. Kisspeptin-1 functions to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Kisspeptin-1 may regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of KISS1 mRNA results in two protein isoforms. Expression of KiSS1 is localized to specific regions of the hypothalamus in numerous species and is regulated by gonadal steroids and across the estrous cycle. Kisspeptin-1 generates a c-terminally amidated peptide, metastin, which functions as the endogenous ligand of the g-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.
Amino Acid Sequence
MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG
Greater than 90.0%
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