Description
Metastasis-suppressor KiSS-1 (Kisspeptin-1) Human, E. coli Recombinant Protein is a single, non-glycosylated polypeptide chain containing 120 amino acids (20-138) and has a molecular mass of 12.6 Dalton. The protein is purified by proprietary chromatographic techniques.
Summary
Metastasis-suppressor KiSS-1 (Kisspeptin-1) is a metastasis suppressor protein that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. Kisspeptin-1 functions to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Kisspeptin-1 may regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of KISS1 mRNA results in two protein isoforms. Expression of KiSS1 is localized to specific regions of the hypothalamus in numerous species and is regulated by gonadal steroids and across the estrous cycle. Kisspeptin-1 generates a c-terminally amidated peptide, metastin, which functions as the endogenous ligand of the g-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.
Other Names
Kisspeptin-1, KISS-1, METASTIN, Metastasis-suppressor KiSS-1, KISS1, MGC39258.
Amino Acid Sequence
MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG
Type
Recombinant Protein
Source
E. coli
Purity
Greater than 90.0%
Formulation
Shipping
Shipped on regular ice packs. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Usage
This product is intended for Laboratory Research Use Only. Not for use in diagnostic or therapeutic procedures. This product may not be used as a pharmaceutical or veterinary drug, agricultural product, or food additive.