Sincalide is a synthetic C-terminal octapeptide identical to the sequences of the endogenous cholecystokinin hormone (CCK-8). Mimicking action of cholecystokinin, sincalide induces gallbladder smooth muscle contraction directly, thereby reducing gallbladder size, inducing bile evacuation, and secretion of pancreatic enzymes. In addition, this agent decreases esophageal sphincter tone and delays gastric emptying via cholinergic signaling.
CAS Registry No.
Amino Acid Sequence
Synthetic peptide hormone
Greater than 99.0% as determined by RP-HPLC.
Sterile-filtered white lyophilized (freeze-dried) powder. The Sincalide was lyophilized from a concentrated (1 mg/ml) solution with no additives.
It is recommended to reconstitute the lyophilized Sincalide in sterile 18MΩ-cm H2O at a concentration of 0.5 mg/ml, which can then be further diluted to other aqueous solutions.
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Lyophilized Sincalide, although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution, Sincalide should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
This product is intended for Laboratory Research Use Only. Not for use in diagnostic or therapeutic procedures. This product may not be used as a pharmaceutical or veterinary drug, agricultural product, or food additive.