Gonadotropin-Releasing Hormone (GnRH) Human, also known as Luteinizing-hormone releasing hormone (LHRH), recombinantly produced in E. coli cells, is a non-glycosylated polypeptide chain containing 92 amino acids (24-92 a.a.) and has a molecular mass of 10.3kDa.
GnRH is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
At the pituitary, GnRH stimulates the synthesis and secretion of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from androgens and estrogens. Low frequency GnRH pulses lead to FSH release, whereas high frequency GnRH pulses stimulate LH release.
There are differences in GnRH secretion between males and females. In males, GnRH is secreted in pulses at a constant frequency, but in females the frequency of the pulses varies during the menstrual cycle and there is a large surge of GnRH just before ovulation.
GnRH secretion is pulsatile in all vertebrates, and is necessary for correct reproductive function. Thus, a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male.
E. coli cells
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSQHWSYGL RPGGKRDAEN LIDSFQEIVK EVGQLAETQR FECTTHQPRS PLRDLKGALE SLIEEETGQK KI.
Greater than 90%.
Sterile filtered colorless solution. GnRH protein solution (0.5 mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Shipped on regular ice packs. Upon receipt, store at the temperature recommended below.
Avoid multiple freeze-thaw cycles.
Luteinizing hormone-releasing hormone I, Luteinising-hormone releasing hormone, LHRH, GRH, GNRH, LNRH, LH-RH I, Gonadotropin-releasing hormone I, GnRH-I, GNRH1, Luliberin I, Gonadorelin, Gonadoliberin I, Gonadoliberin-1, Progonadoliberin I, Progonadoliberin-1, GnRH-associated peptide 1, GnRH-associated peptide I
This product is intended to Laboratory Research Use Only. This product may not be used a drug, agricultural product, food additives.