Gonadotropin-Releasing Hormone (GnRH) Human, E. coli Recombinant, also known as Luteinizing-hormone releasing hormone (LHRH), is a non-glycosylated polypeptide chain containing 92 amino acids (24-92 a.a.) and has a molecular mass of 10.3 kDa. GnRH is fused to a 23 amino acid His-tag at N-terminus and is purified by proprietary chromatographic techniques.
GnRH is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
At the pituitary, GnRH stimulates the synthesis and secretion of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from androgens and estrogens. Low frequency GnRH pulses lead to FSH release, whereas high frequency GnRH pulses stimulate LH release.
There are differences in GnRH secretion between males and females. In males, GnRH is secreted in pulses at a constant frequency, but in females the frequency of the pulses varies during the menstrual cycle and there is a large surge of GnRH just before ovulation.
GnRH secretion is pulsatile in all vertebrates, and is necessary for correct reproductive function. Thus, a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male.
Luteinizing hormone-releasing hormone I, Luteinising-hormone releasing hormone, LHRH, GRH, GNRH, LNRH, LH-RH I, Gonadotropin-releasing hormone I, GnRH-I, GNRH1, Luliberin I, Gonadorelin, Gonadoliberin I, Gonadoliberin-1, Progonadoliberin I, Progonadoliberin-1, GnRH-associated peptide 1, GnRH-associated peptide I
E. coli cells
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSQHWSYGL RPGGKRDAEN LIDSFQEIVK EVGQLAETQR FECTTHQPRS PLRDLKGALE SLIEEETGQK KI.
Greater than 90%.
Sterile filtered colorless solution. GnRH protein solution (0.5 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 20% glycerol and 1 mM DTT.
Shipped on regular ice packs. Upon receipt, store at the temperature recommended below.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
This product is intended for Laboratory Research Use Only. Not for use in diagnostic or therapeutic procedures. This product may not be used as a pharmaceutical or veterinary drug, agricultural product, or food additive.
- Gonadotropin Hormones
- Gonadotropin-Releasing Hormone (GnRH) Human, Synthetic
- Follicle Stimulating Hormone (FSH) Human, Native Protein
- Follicle Stimulating Hormone (FSH) Human, HEK293 Recombinant
- Luteinizing Hormone (LH) Porcine, Native Protein
- Pregnant Mare Serum Gonadotropin (PMSG)
- Human Chorionic Gonadotropin (hCG)