Description
Native L-Asparaginase enzyme purified from E. coli. L-Asparaginase GMP-Grade is manufactured in a certified facility with animal component free certified raw materials.
L-Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine amino acid into aspartic acid and ammonia.
Summary
L-Asparaginase is an enzyme that depletes L-Asparagine, an important nutrient for cancer cells, resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E. coli which can inhibit the growth of malignant cells. It is used mainly for the induction of remission in acute lymphoblastic leukemia. Because of the lymph node origin of malignant B cells in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and, consequently, L-Asparaginase may be of value in managing the disease. The rationale behind asparaginase is that it takes advantage of the fact that acute lymphoblastic leukemia cells are unable to synthesize the non-essential amino acid asparagine whereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase catalyzes the conversion of L-asparagine to aspartic acid and ammonia. This deprives the leukemic cell of circulating asparagine.
Characteristics & Specifications
Each batch is tested and released as per specifications to achieve consistent product quality.
| CAS Registry No. | 9015-68-3 |
| Source | Purified from E. coli |
| Formulation | Lyophilized powder with no additives |
| Appearance | White crystalline powder |
| pH Value | 6.5 - 7.5 |
| Solubility |
Freely soluble in water and insoluble in ethanol |
| Loss on drying |
Not more than 5.0% |
| Identification by chemical method |
A blue violet color should be developed |
| Purity by SEC-HPLC | Purity not less than 98.0% |
| Potency (enzyme activity) |
Not less than 140 IU/mg |
| Specific activity | Not less than 250 IU/mg |
| Bacterial endotoxin | Not more than 0.015 EU/IU |
| Heavy metals | Not more than 0.002% |
| Manufacturer | Provis Biolabs |
| Country of Origin | India |
Shipping
Ships frozen on dry ice. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store at -20°C. Please prevent freeze-thaw cycles.
Usage
This product is intended for Laboratory Research Use Only. Not for use in diagnostic or therapeutic procedures. This product may not be used as a pharmaceutical or veterinary drug, agricultural product, or food additive.
Other Names
L-ASNase, L-asparagine amidohydrolase, ansA, bulk L-Asparaginase, GMP L-Asparaginase
Resources
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Example Certificate of Analysis (CoA)
- Bulk quantities available, please contact us
Ilex Life Sciences LLC is an authorized distributor of Provis Biolabs pvt Ltd.