Matrix Gla Protein (MGP) Human, E. coli Recombinant Protein is a single, non-glycosylated polypeptide chain containing 98 amino acids (20-96) and has a molecular mass of 11.8 kDa. The MGP is fused to a 20 amino acid His-Tag at N-terminus and is purified by proprietary chromatographic techniques.
Matrix Gla protein (MGP) is a member of a family of vitamin-K2 dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. MGP is vital for the regulation of calcification in the extracellular matrix, particularly in cartilage and arteries.
Matrix Gla protein, Cell growth-inhibiting gene 36 protein, GIG36, MGLAP, NTI.
Source: Nishimoto, S. K., & Nishimoto, M. (2014). Matrix gla protein binds to fibronectin and enhances cell attachment and spreading on fibronectin. International journal of cell biology, 2014, 807013. https://doi.org/10.1155/2014/807013
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MYESHESMES YELNPFINRR NANTFISPQQ RWRAKVQERI RERSKPVHEL NREACDDYRL CERYAMVYGY NAAYNRYF
Greater than 90%.
Sterile-filtered colorless solution. The MGP solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Shipped on regular ice packs. Upon receipt, store the product at the temperature recommended below.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
This product is intended for Laboratory Research Use Only. Not for use in diagnostic or therapeutic procedures. This product may not be used as a pharmaceutical or veterinary drug, agricultural product, or food additive.
Want to learn more about MGP? We have compiled the links below which contain information that you may find interesting.
- UniProt Knowledgebase: UniProtKB - P08493 (MGP_HUMAN): Matrix Gla protein
- PubChem Gene Summary: MGP - matrix Gla protein (human)
- Blog: Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin