Nanopia KL-6 Reagents Kit
Nanopia KL-6 Reagent 1
Nanopia KL-6 Reagent 2
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Nanopia® KL-6 Assay

466175
Regular price
$2,495.00
Sale price
$2,495.00
Regular price
$2,938.00
Available January 20th
Unit price
per 
Shipping calculated at checkout.


Product Brochure

Description

The Nanopia® KL-6 Assay, developed and manufactured in Japan by Sekisui Medical Co., Ltd., is a latex agglutination immunoturbidimetric assay for the quantitative measurement of sialylated carbohydrate antigen (KL-6) concentration in serum or plasma.

Krebs von den Lungen 6 (KL-6) is a sialylated carbohydrate antigen that was detected by Kohno et al. in 1985. It is a high molecular weight glycoprotein that is expressed by type II alveolar epithelial cells and is a mucin which belongs to MUC-1 in cluster 9. 

KL-6 has been investigated as an important biomarker that is directly associated with the pathogenic process of interstitial lung disease (ILD), reflecting the extent of damage and regeneration of type II pneumocytes.  It has been confirmed that the serum KL-6 level is significantly higher in subjects with interstitial pneumonia than in healthy volunteers or subjects with other respiratory diseases, and it has been shown by ROC analysis that serum KL-6 is a diagnostically useful indicator.  Serum KL-6 levels may reflect connective tissue disease-associated interstitial lung disease severity.

Type

Immunoturbidimetric assay

Other names

Krebs von den Lungen 6, Sialylated Carbohydrate Antigen, Mucin-1, Mucin 1, MUC-1, MUC1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227

Principle of Method

Sialylated carbohydrate antigen KL-6 (KL-6) in samples agglutinates with mouse KL-6 monoclonal antibody coated latex through the antigen-antibody reaction. The change in absorbance caused by this agglutination is measured to determine the KL-6 level.

Sample Types

Serum, Plasma

Sample Volume

2.5 µL

Calibration Range

105.3 - 401.2 U/mL

Dilution Linearity

50-5000 U/mL

Within Run Precision

1.4 %

Resources

KL-6 Components Available

Cat. No.                Description                                   Size

466175                 Nanopia KL-6 Reagent 1              2 x 24 mL

466199                 Nanopia KL-6 Reagent 2              2 x 8 mL

536519                 Nanopia KL-6 Calibrator Set        1 mL x 4 levels

516214                 Nanopia KL-6 Control Set            2 levels, 3 x 1 mL each level

KL6SET                 Nanopia KL-6 Complete Kit          466175+466199 +536519+516214

References to Summary

  • Kohno N. Med J, Hiroshima Univ, 33, 971:1985.
  • Kohno N. Respiration, 16, 391:1997.
  • Kohno N., et al. Japan J Clin Exper Med, 75, 217:1998.
  • Hirasawa et. al. Am J Resp Cell and Mol Biol, 17, 501: 1997.
  • Lee, J.S., Lee, E.Y., Ha, YJ. et al. Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease. Arthritis Res Ther 21, 58 (2019). https://doi.org/10.1186/s13075-019-1835-9

Resources

Want to learn more about KL-6? We have compiled the links below which contain information that you may find interesting:

Ilex Life Sciences LLC is an authorized distributor of Nanopia® KL-6 Reagents.