Generate clinically relevant quantities of MSCs with beadMATRIX.
Your aim is to generate clinically relevant quantities of mesenchymal stromal cells (MSCs) for cell-based therapies. You have faced difficulties upscaling your expansion process from 2D to 3D while maintaining cell quality, safety, and potency. Ideally, you would like to boost the efficiency of your manufacturing process while standardizing protocols and complying with safety regulations.
beadMATRIX are animal component-free, pre-coated microcarriers specially designed for bioreactor-scale expansion of MSCs in serum-free and xeno-free media. The coating formulation is based on the successful 2D coating product myMATRIX MSC and tailored to support customers in the establishment of translational cell therapies. Documentation describing quality and origin characteristics are provided.
- Acceleration – expand the development capacities of your cell-based product.
- Defined – Serum-free and xeno-free 3D culture.
- Compliant – Fulfilling pharma grade requirements.
Large-scale production of MSCs with consistency across scales – benefit from the isoMATRIX, myMATRIX MSC and beadMATRIX product ecosystem.
Enabling outstanding yield of high quality MSCs
denovoMATRIX has carefully developed a specific coating composition and performed an elaborate optimization process to produce high-performing microcarriers for the 3D culture of MSCs. Application of beadMATRIX accelerates the proliferation of highly viable and therapeutically active MSCs up to 25% compared to the leading brand competitor. Harvested cells show MSC-specific characteristics as defined by the International Society of Cellular Therapy such as distinctive CD-marker expression and trilineage differentiation potential. In addition, they present immunomodulatory potential and angiogenic activity.
Compatible with various manufacturing processes
The upscaling of cell manufacturing is a complex topic. In partnership with denovoMATRIX, we aim to support the establishment and improvement of existing processes with the help of a highly compatible product. beadMATRIX has been successfully tested with different bioreactor setups and several cell culture media. beadMATRIX is ideally suited for use in shaker flasks, shaker bags, stirred tank or vertical wheel bioreactors. beadMATRIX production procedures ensure batch-to-batch consistency, product stability and compliance with the high-quality standards of ISO9001 and ISO14644. beadMATRIX documentation addresses pharma grade requirements in respect of material origin and quality. The microcarriers are sterile and ready-to-use and available in 10 gram units with larger sizes available upon request.
|Bead material||Cross-linked polystyrene|
|Surface charge||Slight cationic charge|
|Relative density range||1.022 – 1.03 g/cm^3|
|Bead size||179 μm ± 10%|
|Specific surface area||330 cm^2/g|
|No. of beads per gram||3.3 x 10^5|
|Appearance||Dry, white to off-white powder|
|Safety||Free of Endotoxins/Animal components/BSE/TSE|
|Application||Sterile product, ready-to-use|
|Certification||ISO9001, pharma grade|
|Quality standards||Manufactured in clean room
ISO14644-1 class 5
|Available formats||10g and 100g / upon request|
- beadMATRIX Product Info Sheet
- White Paper: 3D Manufacturing of Therapeutic hMSCs with RoosterNourish™-XF & beadMATRIX
- beadMATRIX Material Safety Data Sheet (MSDS)
- isoMATRIX: precoated cultureware for isolation of MSCs
- myMATRIX MSC: precoated cultureware for expansion of MSCs
- PowerStem MSC1: xeno-free, serum-free medium for hMSC
Ilex Life Sciences LLC is an authorized distributor of denovoMATRIX beadMATRIX.