denovoMATRIX beadMATRIX for MSCs
beadMATRIX - precoated microcarriers for MSCs culture
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beadMATRIX: precoated microcarriers for MSCs culture

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Generate clinically relevant quantities of MSCs with beadMATRIX.


Your aim is to generate clinically relevant quantities of mesenchymal stromal cells (MSCs) for cell-based therapies. You have faced difficulties upscaling your expansion process from 2D to 3D while maintaining cell quality, safety, and potency. Ideally, you would like to boost the efficiency of your manufacturing process while standardizing protocols and complying with safety regulations.


beadMATRIX are animal component-free, pre-coated microcarriers specially designed for bioreactor-scale expansion of MSCs in serum-free and xeno-free media. The coating formulation is based on the successful 2D coating product myMATRIX MSC and tailored to support customers in the establishment of translational cell therapies. Documentation describing quality and origin characteristics are provided.

beadMATRIX - precoated microcarriers for MSCs culture


  • Acceleration – expand the development capacities of your cell-based product.
  • Defined – Serum-free and xeno-free 3D culture.
  • Compliant – Fulfilling pharma grade requirements.

Large-scale production of MSCs with consistency across scales – benefit from the isoMATRIX, myMATRIX MSC and beadMATRIX product ecosystem.

Enabling outstanding yield of high quality MSCs

denovoMATRIX has carefully developed a specific coating composition and performed an elaborate optimization process to produce high-performing microcarriers for the 3D culture of MSCs. Application of beadMATRIX accelerates the proliferation of highly viable and therapeutically active MSCs up to 25% compared to the leading brand competitor. Harvested cells show MSC-specific characteristics as defined by the International Society of Cellular Therapy such as distinctive CD-marker expression and trilineage differentiation potential. In addition, they present immunomodulatory potential and angiogenic activity.

Bone marrow-derived mesenchymal stromal cells (MSCs) grown in a serum-free 3D culture setup using beadMATRIX or a competitor product. Cell expansion with beadMATRIX resulted in an increased yield (A) of highly viable MSCs (B).

Compatible with various manufacturing processes

The upscaling of cell manufacturing is a complex topic. In partnership with denovoMATRIX, we aim to support the establishment and improvement of existing processes with the help of a highly compatible product. beadMATRIX has been successfully tested with different bioreactor setups and several cell culture media. beadMATRIX is ideally suited for use in shaker flasks, shaker bags, stirred tank or vertical wheel bioreactors. beadMATRIX production procedures ensure batch-to-batch consistency, product stability and compliance with the high-quality standards of ISO9001 and ISO14644. beadMATRIX documentation addresses pharma grade requirements in respect of material origin and quality. The microcarriers are sterile and ready-to-use and available in 10 gram units with larger sizes available upon request.

beadMATRIX is designed for the use in closed and controlled culture devices, e.g., stirredtank bioreactor. Simply combine media, MSCs and microcarriers, and run your processes.


Bead material Cross-linked polystyrene
Coating Biofunctional polymer
Surface charge Slight cationic charge
Relative density range 1.022 – 1.03 g/cm^3
Bead size 179 μm ± 10%
Specific surface area 330 cm^2/g
No. of beads per gram 3.3 x 10^5
Appearance Dry, white to off-white powder
Safety Free of Endotoxins/Animal components/BSE/TSE
Application Sterile product, ready-to-use
Certification ISO9001, pharma grade
Quality standards Manufactured in clean room
ISO14644-1 class 5
Available formats 30 g (3 x 10 g). For larger quantities, please request a quote.


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Ilex Life Sciences LLC is an authorized distributor of denovoMATRIX beadMATRIX.